Patterns of tau pathology identified with 18 F-MK-6240 PET imaging Positron emission tomography (PET) imaging for neurofibrillary tau allows investigation of the in vivo spatiotemporal progression of Alzheimer’s disease (AD) pathology.
New PET imaging tracer helps spot signs of Alzheimer’s disease years before symptoms appear A new positron emission tomography radiotracer has the potential to spot signs of Alzheimer’s disease years before symptoms appear
Case Report: 18F-MK6240 Tau Positron Emission Tomography Pattern Resembling Chronic Traumatic Encephalopathy in a Retired Australian Rules Football Player https://www.frontiersin.org/articles/10.3389/fneur.2020.598980/full
Pascoal TA, Therriault J, et al. 18F-MK-6240 PET for early and late detection of neurofibrillary tangles. Brain. 2020; awaa180. https://doi.org/10.1093/brain/awaa180
Betthauser TJ, Koscik RL, Jonaitis EM, et al. Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age. Brain. 2020; 143(1):320-335. Doi: 10.1093/brain/awz378. https://academic.oup.com/brain/article/143/1/320/5689568
Koscik RL, Betthauser TJ, Jonaitis EM, et al. Amyloid duration is associated with preclinical cognitive decline and tau PET. Alzheimers Dement (Amst). 2020;12(1):e12007. Doi: 10.1002/dad2.12007. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085284/
Therriault J, Benedet AL, Pascoal TA, et al. Association of apolipoprotein E ε4 with medial temporal tau independent of amyloid-β. JAMA Neurol. 2020; 77(4):470-479. Doi: 10.1001/jamaneurol.2019.4421. https://pubmed.ncbi.nlm.nih.gov/31860000/
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